The Rafters is constructed of narrow walkways. If you fall from Rafters 1, you will land on the previous floor and take damage. If you fall from Rafters 2, you might land on a walkway in Rafters 2, but most likely will land on that same floor in the hotel proper and take even more damage. Jumping off can be a fine escape if you have enough health.
It easy to get surrounded, confused, or pushed off the walkways because of the monsters found here: Brawlers, Bats, Demon Bats, Toadstools, and Goblin Anarchists.